TL;DRAbstract
The remarkable ability of the brain to interpret vast amounts of stimuli and adapt to new situations is dependent upon not only the proper formation, but also the functional specialization of synaptic connections between neurons. On the molecular level, we are just beginning to understand the networks that regulate synapse development, termed synaptic organizing complexes. Recent work has identified a number of different proteins required for the formation of synapses, i.e. synaptogenesis. However, much less is understood about the protein networks that guide the maintenance and maturation of these nascent synapses. Here, I describe a novel synaptic organizing complex comprised of the secreted protein LGI1 and its transmembrane partners, ADAM22 and ADAM23. I present data demonstrating that LGI1 mediates a transsynaptic complex, including pre- and postsynaptic ADAMs and members of the MAGUK family of intracellular scaffolding proteins. I go on to characterize the functional impact of th
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The remarkable ability of the brain to interpret vast amounts of stimuli and adapt to new situations is dependent upon not only the proper formation, but also the functional specialization of synaptic connections between neurons. On the molecular level, we are just beginning to understand the networks that regulate synapse development, termed synaptic organizing complexes. Recent work has identified a number of different proteins required for the formation of synapses, i.e. synaptogenesis. However, much less is understood about the protein networks that guide the maintenance and maturation of these nascent synapses. Here, I describe a novel synaptic organizing complex comprised of the secreted protein LGI1 and its transmembrane partners, ADAM22 and ADAM23. I present data demonstrating that LGI1 mediates a transsynaptic complex, including pre- and postsynaptic ADAMs and members of the MAGUK family of intracellular scaffolding proteins. I go on to characterize the functional impact of th
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