Impact of High-Dose Early Mobilization on Outcomes for Patients with Diabetes: A Secondary Analysis of the TEAM Trial

TL;DRAbstract

<b>Rationale:</b> Patients with diabetes represent almost 20% of all ICU admissions and might respond differently to high-dose early active mobilization. <b>Objectives:</b> To assess whether diabetes modified the relationship between the dose of early mobilization on clinical outcomes in the TEAM trial. <b>Methods:</b> All TEAM trial patients were included. The primary outcome was days alive and out of the hospital at Day 180. Secondary outcomes included 180-day mortality and long-term functional outcomes at Day 180. Logistic and median regression models were used to explore the effect of high-dose early mobilization on outcomes by diabetes status. <b>Measurements and Main Results:</b> All 741 patients from the original trial were included. Of these, 159 patients (21.4%) had diabetes. Patients with diabetes had fewer days alive and out of the hospital at Day 180 (124 [0-153] vs. 147 [82-164]; <i>P</i> = 0.013) and higher 180-day mortality (30% vs. 18%; <i>P</i> = 0.044). In patients re

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