第8回日本ステロイドホルモン学会
TL;DRAbstract
An isolated adrenocortical cell deprived of its tissue integrity, input from the nervous system , or intercellular communication with chromaffin, vascular, and immune cells of the adrenal gland, loses its normal capacity to produce glucocorticoids and to adequately respond to the homeostatic challenges of stress. We have recently shown that adrenocortical cells in co-culture with chromaffin cells produce ten times more glucocorticoids than the same number of pure adrenocortical cells and demonstrate a marked up-regulation in the mRNA expression of cytochrome p450 enzymes in co-culture, while this expression is down-regulated in isolated cells.
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An isolated adrenocortical cell deprived of its tissue integrity, input from the nervous system , or intercellular communication with chromaffin, vascular, and immune cells of the adrenal gland, loses its normal capacity to produce glucocorticoids and to adequately respond to the homeostatic challenges of stress. We have recently shown that adrenocortical cells in co-culture with chromaffin cells produce ten times more glucocorticoids than the same number of pure adrenocortical cells and demonstrate a marked up-regulation in the mRNA expression of cytochrome p450 enzymes in co-culture, while this expression is down-regulated in isolated cells.
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