Cell Trapping in Activated Micropores for Functional Analysis

doi:https://doi.org/10.1109/iembs.2006.260233

Review10.1109/iembs.2006.260233

Cell Trapping in Activated Micropores for Functional Analysis

AmirAli Talasaz,Ashley A. Powell,Patrik L. Ståhl,Mostafa Ronaghi,Stefanie S. Jeffrey,Michael Mindrinos+1 more-2006-08-01

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TL;DRAbstract

This paper presents a novel device which provides the opportunity to perform high-throughput biochemical assays on different individual cells. In particular, the proposed device is suited to screen the rare cells in biological samples for early stage cancer diagnosis and explore their biochemical functionality. In the process, single cells are precisely positioned and captured in activated micropores. To show the performance of the proposed device, cultured yeast cells and human epithelial circulating tumor cells are successfully captured.

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This paper presents a novel device which provides the opportunity to perform high-throughput biochemical assays on different individual cells. In particular, the proposed device is suited to screen the rare cells in biological samples for early stage cancer diagnosis and explore their biochemical functionality. In the process, single cells are precisely positioned and captured in activated micropores. To show the performance of the proposed device, cultured yeast cells and human epithelial circulating tumor cells are successfully captured.

Keywords

Yeast Cell Cell biology Throughput Computer science Process (computing)Cancer cell Nanotechnology

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