Sedative Drug Modulates T-Cell and Lymphocyte Function-Associated Antigen-1 Function

doi:https://doi.org/10.1213/ane.0b013e31820dcabb

Open AccessArticle10.1213/ane.0b013e31820dcabb

Sedative Drug Modulates T-Cell and Lymphocyte Function-Associated Antigen-1 Function

Koichi Yuki,Sulpicio G. Soriano,Motomu Shimaoka-2011-03-09-Anesthesia & Analgesia

39

TL;DRAbstract

Our study suggests that propofol competitively inhibits LFA-1 binding to ICAM-1 on T-cells and suppresses T-cell proliferation and IL-2 production, whereas dexmedetomidine and midazolam do not significantly influence these immunological assays.

Chat with Paper

AI Agents for this Paper

Our study suggests that propofol competitively inhibits LFA-1 binding to ICAM-1 on T-cells and suppresses T-cell proliferation and IL-2 production, whereas dexmedetomidine and midazolam do not significantly influence these immunological assays.

Keywords

Immune system Medicine Lymphocyte function-associated antigen 1 Pharmacology Peripheral blood mononuclear cell Lymphocyte T cell Immunology

Chat

Click to start Chat