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Book Chapter10.1007/978-1-62703-170-7_11

T-Cell Malignancies in Children and Adolescents: State of the Clinical and Biological Science

Nader Kim El‐Mallawany,Pieter Van Vlierberghe,Adolfo A. Ferrando,Megan S. Lim,Mitchell S. Cairo-2012-09-23-Humana Press eBooks
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TL;DRAbstract

T-cell malignancies are neoplasms that arise from cells of the innate and adaptive immune system. They are rare in the Western hemisphere and more so in children and young adolescents. They exhibit tremendous clinical and molecular heterogeneity and can pose diagnostic and therapeutic challenges for the oncology community. The recent World Health Organization classification outlines over 20 distinct subtypes of T-cell malignancies. In this chapter we provide an in-depth overview of the state of the clinical and biological science of T-cell malignancies with a focus on the three most common subtypes, T lymphoblastic leukemia/lymphoma, and anaplastic large cell lymphoma.

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T-cell malignancies are neoplasms that arise from cells of the innate and adaptive immune system. They are rare in the Western hemisphere and more so in children and young adolescents. They exhibit tremendous clinical and molecular heterogeneity and can pose diagnostic and therapeutic challenges for the oncology community. The recent World Health Organization classification outlines over 20 distinct subtypes of T-cell malignancies. In this chapter we provide an in-depth overview of the state of the clinical and biological science of T-cell malignancies with a focus on the three most common subtypes, T lymphoblastic leukemia/lymphoma, and anaplastic large cell lymphoma.

Keywords

State (computer science)PsychologyDevelopmental psychologyMedicinePolitical scienceComputer science

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