探討巨噬細胞NOD2在Toll-Like Receptor 4的訊息傳遞及誘發的發炎基因表現中所扮演的角色

TL;DRAbstract

NOD2 of NLR family has an important role in innate immunity as the cytosolic sensor of microbial components derived from bacterial peptidoglycan. Recent reports indicated that mutations in the leucine-rich repeat (LRR) domain of NOD2 have been implicated in the pathogenesis of Crohn’s disease (CD), yet the function of NOD2 and regulation of the NOD2 pathway remain unclear. Moreover, Toll-like receptor (TLR) is a major family of pattern recognition receptors (PRRs) and plays a crucial role in innate immune system. Recently, TLR4 is strongly up-regulated in both ulcerative colitis and CD. TLR4 polymorphisms (Asp299Gly and Thr399Ile) have been described in CD. Molecular interaction between TLR- and NOD2-signaling pathways is still controversial. Herein, we investigated the role of NOD2 in TLR-mediated signaling and gene regulation in murine macrophages. In murine RAW 264.7 macrophages, MDP (NOD2 ligand) can further increase LPS-induced pro-inflammatory cytokines and mediators, including T

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