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Open AccessBook Chapter10.1007/978-1-59259-401-6_2

p27, A Prognostic Indicator Reflecting ...?

Andrew Koff-2003-01-01-Humana Press eBooks
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TL;DRAbstract

Over the last five years, the expression of p27kipl, a cyclin-dependent kinase inhibitor, has proved to be a strong prognostic indicator for long-term survival of patients with tumors of the colon, breast, prostate, lung, pituitary, and many other tissues. Tumors arising in these organs that were not expressing p27 protein tended to be more aggressive and patients had a poorer clinical outcome. However, it is not clear why p27 was such a strong prognostic indicator in multiple tissues. Furthermore, before p27 is brought into widespread clinical use, prospective studies will be required to validate, in advance, a clinical course or response to therapy. Without the essential knowledge of what low p27 prognosticates, vis a vis the evolution of the tumor, validation will be difficult. Because there is no possibility of determining directly how low p27 expression facilitates tumor development in humans, we have turned to developing mouse models. However, we had to first ask the following qu

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Over the last five years, the expression of p27kipl, a cyclin-dependent kinase inhibitor, has proved to be a strong prognostic indicator for long-term survival of patients with tumors of the colon, breast, prostate, lung, pituitary, and many other tissues. Tumors arising in these organs that were not expressing p27 protein tended to be more aggressive and patients had a poorer clinical outcome. However, it is not clear why p27 was such a strong prognostic indicator in multiple tissues. Furthermore, before p27 is brought into widespread clinical use, prospective studies will be required to validate, in advance, a clinical course or response to therapy. Without the essential knowledge of what low p27 prognosticates, vis a vis the evolution of the tumor, validation will be difficult. Because there is no possibility of determining directly how low p27 expression facilitates tumor development in humans, we have turned to developing mouse models. However, we had to first ask the following qu

Keywords

MedicineProstateCancer researchOncologyInternal medicineCancer

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