Plasma potassium concentrations after severe controlled hemorrhage in inbred rat strains

TL;DRAbstract

Arterial plasma potassium concentrations [K + ] a increase after severe hemorrhage (Shires et al., Ann Surg 176:288, 1972)‐‐ which is consistent with decreased activity of ATP‐dependent Na/K ATPase (Darlington and Gann, J Trauma 58: 1, 2005)‐‐ and are significantly higher in non‐survivors vs survivors after hemorrhage (Torres et al., Am J Physiol 286: H1811, 2004). Eight‐fold differences in survival time were detected among 15 inbred rat strains after a controlled hemorrhage without resuscitation (Klemcke et al., Shock , in press, 2007). To assess potential mechanisms of these differences, [K + ] a was measured at the beginning (basal) and end (final) of hemorrhage in those 15 inbred strains. Rats (n = 8–11/strain)were catheterized and, 24 hours later, 55% of the blood volume was removed during a 26 min period from conscious unrestrained animals. Rats were then observed for 6 hr or until death. Using average values for each strain, there were correlations between survival time and basa

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