Determinations of Drug Counter-Ions and Ionic Impurities by CE
TL;DRAbstract
The separation and detection of simple small inorganic and organic ions is an important activity in many industries. Ion-exchange chromatography and flame AAS are frequently used as analytical testing techniques to determine levels of these ions. Increasingly CE is being viewed (1–25) as a viable alternative to these established techniques for many applications as CE can offer benefits in terms of simplicity and reduced analysis time and costs. Table 5.1 shows the range of determinations that CE has been applied to in the area. The uptake of CE to determine small ions has been considerable, a recent survey (26) indicated that it constituted 11 % of the current workload of CE in pharmaceutical analysis laboratories. A further survey (27) showed that the determination of small ions was amongst the most frequent uses of CE across all industries.
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The separation and detection of simple small inorganic and organic ions is an important activity in many industries. Ion-exchange chromatography and flame AAS are frequently used as analytical testing techniques to determine levels of these ions. Increasingly CE is being viewed (1–25) as a viable alternative to these established techniques for many applications as CE can offer benefits in terms of simplicity and reduced analysis time and costs. Table 5.1 shows the range of determinations that CE has been applied to in the area. The uptake of CE to determine small ions has been considerable, a recent survey (26) indicated that it constituted 11 % of the current workload of CE in pharmaceutical analysis laboratories. A further survey (27) showed that the determination of small ions was amongst the most frequent uses of CE across all industries.
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