雾化吸入糖皮质激素对支气管哮喘患儿下丘脑－垂体－肾上腺轴功能的影响

TL;DRAbstract

Objective To evaluate the effect of nebulized corticosteroid-Budesonide (BUD) on hypothalamic-pituitary-adrenal axis (HPAA) in children with asthma. Methods 1. Thirty children with mild to moderate persistent asthma (observation group) were treated with inhaled BUD, before treatment and 6 weeks after treatment, the levels of serum cortisol and 24-hour urine free cortisol (24 h-UFC), were measured and compared with those in healthy children, 12 weeks after treatment another observation of 24 h-UFC was made in BUD treated asthmatic children. 2. Sixty asthmatic children who had regularly treated with BUD through jet nebulizer for more than 6 months were divided into 2 groups: BUD-250 group (those asthmatic children who had received 250 μg/d of BUD for more than 3 months) and BUD 500 group (those asthmatic children who had received 500 μg/d of BUD for more than 3 months) according to the given dose of BUD at 3 months just before our investigation. The levels of serum cortisol and 24-UFC we

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