Epigenetic regulation in (mid)brain development

TL;DRAbstract

During embryonic development embryonic stem cells (ESCs) become committed to numerous cell-fates and can differentiate in neuronal stem cells (NSCs), which can convert into three different cell-types of the nervous system, neurons, astrocytes, and oligodendrocytes. During this differentiation genes are subject to a massive change in expression. The change in gene expression during development is controlled in many different ways, of which epigenetic control is importantly involved in cell-lineage specification and differentiation into different neuronal subsets.\nMany genes involved in brain development, like bdnf, dlk1, grb10, and dnmt1, 3a and 3b, are epigenetically controlled or control epigenetic changes, either by imprinting, which is a static epigenetic modification, or dynamic modifications on the chromatin. These epigenetic modifications can affect the DNA, methylation and non-coding (nc)RNAs binding gene promoters, the histones, which includes methylation and acetylation, and

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