Classification of T-cell and NK-cell Malignancies

doi:https://doi.org/10.1007/978-1-60761-384-8_22

Book Chapter10.1007/978-1-60761-384-8_22

Classification of T-cell and NK-cell Malignancies

Dan Jones-2009-12-07-Humana Press eBooks

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TL;DRAbstract

This chapter provides an overview of mature T-cell malignancies, including those presenting in lymph nodes (e.g., angioimmunoblastic T-cell lymphoma), extranodal sites (e.g., hepatosplenic T-cell lymphoma), and leukemias (e.g., Sézary syndrome). The role of the two prototypic mature T-cell oncogenes, ALK kinase in anaplastic large cell lymphoma and TCL1 in T-cell prolymphocytic leukemia, is discussed. A general model for T-cell tumor initiation involving canonical and aberrant signaling through the T-cell receptor is presented. The clinical presentation and morphologic range of NK-cell malignancies are also discussed.

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This chapter provides an overview of mature T-cell malignancies, including those presenting in lymph nodes (e.g., angioimmunoblastic T-cell lymphoma), extranodal sites (e.g., hepatosplenic T-cell lymphoma), and leukemias (e.g., Sézary syndrome). The role of the two prototypic mature T-cell oncogenes, ALK kinase in anaplastic large cell lymphoma and TCL1 in T-cell prolymphocytic leukemia, is discussed. A general model for T-cell tumor initiation involving canonical and aberrant signaling through the T-cell receptor is presented. The clinical presentation and morphologic range of NK-cell malignancies are also discussed.

Keywords

Anaplastic large-cell lymphomaT-cell lymphomaCancer researchLymphomaProlymphocytic leukemiaCellT cellCell of origin

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