Aleukemic variant of mast cell leukemia- A rare phenomenon

TL;DRAbstract

Mast cell leukemia is a rare variant of mastocytosis, accounting for less than 1% of all mast cell disease and pose one of the greater challenges in the management of these patients, with a grave prognosis. Diagnosis of this neoplasm rests on the detection of abnormal mast cells in marrow and subsequent spill over to the peripheral blood. We report a case of aleukemic variant of mast cell leukemia in a pediatric patient, presenting with fever and chest pain for 10 days. The peripheral smear showed a picture of pancytopenia with abnormal/ atypical lymphoid cells. Bone marrow aspirate showed dense aggregates of atypical, hypogranular and partially degranulated mast cells expressing toluidine blue and CD117 positivity.

Chat with Paper

AI Agents for this Paper