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Open AccessArticle10.1016/j.toxrep.2015.06.004

Health risk characterization for exposure to benzene in service stations and petroleum refineries environments using human adverse response data

Benjamin Edokpolo,Qi Yu,Des Connell-2015-01-01-Toxicology Reports
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TL;DRAbstract

Health risk characterization of exposure to benzene in service stations and petroleum refineries has been carried out in previous studies using guideline values set by various agencies. In this work, health risk was characterized with the exposure data as cumulative probability distribution (CPD) plots but using human epidemiological data. This was achieved by using lowest observable adverse effects levels (LOAEL) data plotted as cumulative probability lowest effects distribution (CPLED). The health risk due to benzene was characterized by using probabilistic methods of hazard quotient (HQ<sub>50/50</sub> and HQ<sub>95/5</sub>), Monte-Carlo simulation (MCS) and overall risk probability (ORP). CPD relationships of adverse health effects relationships and exposure data were in terms of average daily dose (ADD) and lifetime average daily dose (LADD) for benzene. For service station environments HQ<sub>50/50</sub> and HQ<sub>95/5</sub> were in a range of 0.000071-0.055 and 0.0049-21, respe

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Health risk characterization of exposure to benzene in service stations and petroleum refineries has been carried out in previous studies using guideline values set by various agencies. In this work, health risk was characterized with the exposure data as cumulative probability distribution (CPD) plots but using human epidemiological data. This was achieved by using lowest observable adverse effects levels (LOAEL) data plotted as cumulative probability lowest effects distribution (CPLED). The health risk due to benzene was characterized by using probabilistic methods of hazard quotient (HQ<sub>50/50</sub> and HQ<sub>95/5</sub>), Monte-Carlo simulation (MCS) and overall risk probability (ORP). CPD relationships of adverse health effects relationships and exposure data were in terms of average daily dose (ADD) and lifetime average daily dose (LADD) for benzene. For service station environments HQ<sub>50/50</sub> and HQ<sub>95/5</sub> were in a range of 0.000071-0.055 and 0.0049-21, respe

Keywords

Oil refineryHazard quotientEnvironmental sciencePopulationEnvironmental healthRisk assessmentStatisticsHealth risk

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