TGF-beta Increases CX3CR1 Expression and Attenuates Lipopolysaccharide (LPS) Induced Microglia Activation

TL;DRAbstract

Interactions between Fractalkine (CX3CL1) and Fractalkine receptor (CX3CR1) in the CNS function to modulate the activation of microglia. The Godbout Laboratory has recently reported that CX3CR1 is down regulated on microglia after lipopolysaccharide (LPS) injection and that this down-regulation was protracted (24 h)on microglia of aged mice (20 mo) compared to adult mice (3- 6 mo). This extended reduction in receptor expression in aged microglia corresponded with exaggerated Interleukin 1-b expression and an impaired recovery from the behavioral symptoms of sickness. The underlying cause of the protracted down regulation of the Fractalkine receptor on microglia of aged mice is unknown but may be related to an age-related decrease in levels of the thanti-inflammatory cytokine, Transforming growth factor beta (TGFβ). Therefore, the purpose of this study was to determine the extent to which TGFβ is involved in the regulation of CX3CR1 expression on microglia. In this study cultured BV2 mi

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