Neurotransmitter receptors in three rodent models of Parkinson's disease : a quantitative multireceptor study

TL;DRAbstract

Parkinson’s disease (PD) is the second most common neurodegenerative disorder. Despite ongoing efforts, the knowledge of the etiology and underlying mechanisms resulting in the neurodegenerative processes (e.g., loss of dopaminergic neurons) remains incomplete. Since therapeutic intervention is still limited to symptomatic relief and mainly focused on the dopamine system, the understanding of the role of other, non-dopaminergic systems during pathogenesis of PD has to be improved for identifying new targets for treatment. Neurotransmitter receptors are major targets for pharmaceutical interventions in numerous neurological and psychiatric disorders, since distinct changes of receptors are often found in such diseases. In case of PD, the dominant role of changes in dopaminergic neurotransmission is well known. The possible involvement of other transmitter systems and their receptors, however, is not well understood. Therefore, the aim of this study was the analysis of the density and di

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