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Article10.1055/s-2008-1077235

Akute Hepatitis B - Ist eine antivirale Therapie indiziert?

J. Girke,Heiner Wedemeyer,Johannes Wiegand,M.P. Manns,Hans L. Tillmann-2008-05-01-DMW - Deutsche Medizinische Wochenschrift
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TL;DRAbstract

Recently available nucleos(t)ide analogs, such as entecavir and adefovir, seem to be efficacious in acute hepatitis B therapy when lamivudine has failed. When prothrombin time is substantially prolonged, antiviral therapy is recommended. However, there is no consensus on antiviral therapy of acute hepatitis B in general, because data from large studies are still lacking. The findings described here suggest that such patients with acute hepatitis B should be treated within the German GAHB study (German acute hepatitis B study: www.gahb.de).

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Recently available nucleos(t)ide analogs, such as entecavir and adefovir, seem to be efficacious in acute hepatitis B therapy when lamivudine has failed. When prothrombin time is substantially prolonged, antiviral therapy is recommended. However, there is no consensus on antiviral therapy of acute hepatitis B in general, because data from large studies are still lacking. The findings described here suggest that such patients with acute hepatitis B should be treated within the German GAHB study (German acute hepatitis B study: www.gahb.de).

Keywords

EntecavirAdefovirMedicineLamivudineHepatitis BGastroenterologyLiver functionInternal medicine

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