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The effects of semistarvation and parenteral nutrition on the gastric mucosa of rats.

Oram-Smith Jc,Rosato Ef-1976-03-01-PubMed
15

TL;DRAbstract

The effects of semistarvation and parenteral nutrition on the gastric mucosa were studied in 24 Wistar rats (250 to 350 grams). The animals were divided into three dietary regimens: Group I-standard rat chow ad libitum; Group II-50 cc. per day of a hyperalimentation solution containing 30% glucose + 5% amino acids; Group III-50 cc. per day of 5% glucose. The animals were fed for a period of 7 days. Gastric mucosal fluxes of Na+, Li+, and H+ then were measured after the gastric instillation of two gastric wash solutions, one primarily an HC1 solution, the other a solution of HC1 plus sodium taurocholate. Gross examination of the gastric mucosal surfaces were recorded. Compared to Group I (oral diet), Groups II and III demonstrated a decrease in volume in gastric secretion during the test period (p less than 0.005); and an increase in net negative hydrogen flux (p less than 0.005). Compared to Group II (hyperalimented), Group III (semistarved) demonstrated an increased net negative H+ fl

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The effects of semistarvation and parenteral nutrition on the gastric mucosa were studied in 24 Wistar rats (250 to 350 grams). The animals were divided into three dietary regimens: Group I-standard rat chow ad libitum; Group II-50 cc. per day of a hyperalimentation solution containing 30% glucose + 5% amino acids; Group III-50 cc. per day of 5% glucose. The animals were fed for a period of 7 days. Gastric mucosal fluxes of Na+, Li+, and H+ then were measured after the gastric instillation of two gastric wash solutions, one primarily an HC1 solution, the other a solution of HC1 plus sodium taurocholate. Gross examination of the gastric mucosal surfaces were recorded. Compared to Group I (oral diet), Groups II and III demonstrated a decrease in volume in gastric secretion during the test period (p less than 0.005); and an increase in net negative hydrogen flux (p less than 0.005). Compared to Group II (hyperalimented), Group III (semistarved) demonstrated an increased net negative H+ fl

Keywords

Internal medicineMedicineParenteral nutritionGastric mucosaEndocrinologySodiumStomachGastroenterology

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