Functional characterization of three ABC1-like kinases found in the plastoglobule proteome

TL;DRAbstract

In bacteria and mitochondria, the members of the ABC1/ADCK/UbiB family regulate ubiquinone synthesis, and their mutations cause severe respiration defects, including progressive neurological disorders in humans. Little is known about plant ABC1-like kinases: in <i>Arabidopsis thaliana</i> five are predicted in mitochondria, but surprisingly six are located at lipid droplets (plastoglobules) in chloroplasts. These are a known site of carotenoid (β-carotene, lutein) and prenylquinone (including Vitamin E, K and plastoquinone) metabolism and contain a large proportion of the tocopherol cyclase (VTE1) required for Vitamin E synthesis and Redox recycling. Although the key enzymes involved in carotenoid and prenylquinone biosynthesis are mostly known, the regulation of these pathways is still poorly understood. Therefore, ABC1-like kinases may be suitable candidates for such regulators and be involved in the modulation of chloroplast lipid metabolism. <br> Using a non-targeted lipidomics app

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