Oftalmia Neonatal-Profilaxis con Povidona Iodada y Agentes de Transmissión Vertical: estudio intervencional en dos Unidades Materno-Infantiles en Luanda

TL;DRAbstract

Purpose. To determine the efficacy of povidone-iodine (P-I) prophylaxis for ophthalmia neonatorum (ON) in Angola and to document maternal prevalence and mother-to-child transmission rates. Methods. Endocervical samples from mothers ( = 317) and newborn conjunctival smears ( = 245) were analysed by multiplex polymerase chain reaction (PCR) for Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and Mycoplasma genitalium (MG). Newborns were randomized into a noninterventional group and an interventional group that received a drop of P-I 2.5% bilaterally after conjunctival smear collection. Mothers were trained to identify signs of ON and attend a follow-up visit. Results. Forty-two newborns had ocular pathology, and 11 (4.4%) had clinical signs of ON at the time of delivery. Maternal PCR was positive for MG ( = 19), CT ( = 8), and NG ( = 2). Six newborns were positive for CT ( = 4), MG ( = 2), and NG ( = 1). Mother-to-child transmission rates were 50% for CT and NG and 10.5% for MG.

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