Tumor suppressor proteins restricts LINE-1 retrotransposition
TL;DRAbstract
Background Long interspersed element 1 (LINE-1) is a retroelement comprising about 17% of the human genome, encoding ORF1 with an RNA interaction domain and ORF2 with endonuclease and reverse transcriptase activities. Similar to retroviruses, LINE-1 replicates in the host via an RNA intermediate that is reverse transcribed and integrated into the host genome. LINE-1 retrotransposition has resulted in genetic diseases. In fact, LINE-1 insertion was recently found in several human tumors. However, the life cycle of LINE-1 is not fully understood. Therefore, we examined identification and characterization of host factors affected the retrotransposition of LINE-1.
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Background Long interspersed element 1 (LINE-1) is a retroelement comprising about 17% of the human genome, encoding ORF1 with an RNA interaction domain and ORF2 with endonuclease and reverse transcriptase activities. Similar to retroviruses, LINE-1 replicates in the host via an RNA intermediate that is reverse transcribed and integrated into the host genome. LINE-1 retrotransposition has resulted in genetic diseases. In fact, LINE-1 insertion was recently found in several human tumors. However, the life cycle of LINE-1 is not fully understood. Therefore, we examined identification and characterization of host factors affected the retrotransposition of LINE-1.
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