Avaliação toxicologica e farmacologica do complemento nutricional "TK3"
TL;DRAbstract
xliv 3. In the evaluation of possible gastric cytoprotective mechanisms of action, pre-treatment of experimental rats with indomethacin (5 mg/Kg, p.o.) did not inhibit the antiulcerogenic effect of "TK3" (1000 mg/Kg, p.o.) in the ethanol induced ulcer model; 4. Similarly, pre-treatment of experimental rats with L-NAME (5 mg/Kg, i.v.) did not inhibit the antiulcerogenic effect of "TK3" (1000 mg/Kg, p.o.) in the ethanol induced ulcer model; 5. Finally, pre-treatment of experimental rats with NEM (10 mg/Kg, s.c.) decreased 50% of the antiulcerogenic effect of "TK3" (1000 mg/Kg, p.o.) in the ethanol induced ulcer model, suggesting the participation of endogenous non-protein SH-containing compounds. However, as this reduction was not complete, there seems to be more aspects involved in this mechanism of action.
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xliv 3. In the evaluation of possible gastric cytoprotective mechanisms of action, pre-treatment of experimental rats with indomethacin (5 mg/Kg, p.o.) did not inhibit the antiulcerogenic effect of "TK3" (1000 mg/Kg, p.o.) in the ethanol induced ulcer model; 4. Similarly, pre-treatment of experimental rats with L-NAME (5 mg/Kg, i.v.) did not inhibit the antiulcerogenic effect of "TK3" (1000 mg/Kg, p.o.) in the ethanol induced ulcer model; 5. Finally, pre-treatment of experimental rats with NEM (10 mg/Kg, s.c.) decreased 50% of the antiulcerogenic effect of "TK3" (1000 mg/Kg, p.o.) in the ethanol induced ulcer model, suggesting the participation of endogenous non-protein SH-containing compounds. However, as this reduction was not complete, there seems to be more aspects involved in this mechanism of action.
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