DINAMIKA MOLEKULER GEN HEMAGLUTININ VIRUS AVIAN INFLUENZA SUBTIPE H5N1 YANG DIISOLASI DARI BERBAGAI SPESIES UNGGAS SEJAK TAHUN 2003 SAMPAI 2008

TL;DRAbstract

Outbreak of avian Influenza (AI) in Indonesia has been reported since the mid of 2003, affected to layer commercial farm in Province of Central and West Java. Clinical sign observation since in the early outbreak in the year 2003 to 2008 indicated some variation of symptoms of AI virus infection. Moreover, the AI infections are still existing in the field sporadically, both in farms with and without AI vaccination practices. This study was a retrospective study which was designed to molecularly characterize of hemagglutinin (HA) gene of AI virus, particularly in the fragment of cleavage site (CS), fusion site (FS), receptor binding site (RBS), and antigenic sites (AS). Avian influenza viruses isolated from various poultry since 2003 until 2008 outbreak in Indonesia, which exhibited variation of symptoms and were obtained from farm with and without AI vaccination practices. Isolation and propagation were done on the chicken embryonated egg specific pathogen free. For virus detection and

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