TL;DRAbstract
Several lines of evidence developed in preclinical models suggest that both spontaneous pain and evoked pain are mediated in part by voltage-dependent calcium channels (VDCCs) []. Both the central and peripheral nervous systems have an abundance of calcium channels. However, in addition to their roles in sensory processing, VDCCs play critical roles in various physiological processes including cardiac electrophysiology, vascular tone, motor control and other neural communication. The ubiquity and importance of VDCCs naturally raises concerns that drug-induced blockade could have adverse impact on multiple physiological systems. The number of subtypes of VDCC that has been recognized to date gives hope, however, that just as it has been possible to use subtype-selective VDCC antagonists as antihypertensive and antiarrhythmic drugs, it may be possible to selectively modulate subytpes involved in painful sensations without unacceptable side effects.
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Several lines of evidence developed in preclinical models suggest that both spontaneous pain and evoked pain are mediated in part by voltage-dependent calcium channels (VDCCs) []. Both the central and peripheral nervous systems have an abundance of calcium channels. However, in addition to their roles in sensory processing, VDCCs play critical roles in various physiological processes including cardiac electrophysiology, vascular tone, motor control and other neural communication. The ubiquity and importance of VDCCs naturally raises concerns that drug-induced blockade could have adverse impact on multiple physiological systems. The number of subtypes of VDCC that has been recognized to date gives hope, however, that just as it has been possible to use subtype-selective VDCC antagonists as antihypertensive and antiarrhythmic drugs, it may be possible to selectively modulate subytpes involved in painful sensations without unacceptable side effects.
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