Controlled drug delivery of L-arginine from a polymer matrix

TL;DRAbstract

This work concerns the development of controlled drug delivery systems, for the application in modern wound management. Two approaches are traced in order to ensure a drug supply of the wound, as long as possible. First, a controlled drug delivery system was developed to be embedded into a polyurethane based wound covering. Second, the aim was to develop and investigate an aqueous system, which can be applied directly to the wound, prior to using a wound covering. For the first approach, silicone microparticles were developed, containing crystalline L-arginine. And indeed, the silicone microparticles provide both, an almost linear release and a release over several days. Furthermore, the release kinetics was further investigated, in dependence of the particle size, the L-arginine content in the particles, the pH value of the release medium and some other parameter. Moreover, proliferation and toxicity cell experiments were performed, using cell types which are involved in wound healing

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