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Background: Radical cystectomy offers the best opportunity for ultimate cure of high-grade and high-risk invasive bladder cancer. Objective: To review the available literature on the indication and oncological outcome of radical cystectomy for urothelial carcinoma of the bladder. A database search of the U.S. National Library of Medicine (PubMed) was performed for relevant medical articles using the Medical Subject Headings “invasive bladder cancer” and “radical cystectomy” with restrictions to English language publications. Evidence: Immediate or early radical cystectomy offers excellent recurrence-free and disease-specific survival rates as well as local tumor control in patients with organ-confined and node-negative disease. Tumor control in nonorgan-confined tumors is satisfactory with long-term recurrence-free survival rates of about 50%. For node-positive disease, surgery may still be curative in approximately one-fourth of patients. Conclusions: Evidence from the literature supp
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Background: Radical cystectomy offers the best opportunity for ultimate cure of high-grade and high-risk invasive bladder cancer. Objective: To review the available literature on the indication and oncological outcome of radical cystectomy for urothelial carcinoma of the bladder. A database search of the U.S. National Library of Medicine (PubMed) was performed for relevant medical articles using the Medical Subject Headings “invasive bladder cancer” and “radical cystectomy” with restrictions to English language publications. Evidence: Immediate or early radical cystectomy offers excellent recurrence-free and disease-specific survival rates as well as local tumor control in patients with organ-confined and node-negative disease. Tumor control in nonorgan-confined tumors is satisfactory with long-term recurrence-free survival rates of about 50%. For node-positive disease, surgery may still be curative in approximately one-fourth of patients. Conclusions: Evidence from the literature supp
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