Distribution and regulation of neuropeptide Y and its receptors in the human and rat brain : role in affective disorders

TL;DRAbstract

<p>Neuropeptide Y (NPY) is one of the most abundant peptides found within the mammalian brain. Many studies have documented that this 36-amino acid peptide exerts a wide range of central effects. In the CNS, the physiological actions of NPY are thought to be primarily mediated via interactions at six NPY receptor subtypes, Y1-Y6, which have distinct anatomical distribution and pharmacological properties. Based on the limited information known about the anatomical organization of the NPY system in the human central nervous system (CNS), the regional mRNA expression of NPY and its receptors, Y1 and Y2, were analyzed in the post-mortem human brain.</p><p>The results of these studies demonstrated that there is a differential distribution of Y1 and Y2 mRNA-expressing cells in the human brain, with Y1 prevalent in most neocortical regions as well as in the striatum, while Y2 mRNA expression is most abundant in the hippocampus and the cerebellum. Using double labeling in sit

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