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Article10.1177/000348941312200405

Protective Effects of Exogenous Surfactant Protein A in Allergic Rhinitis: A Mouse Model

Jie Ren,Yuqin Deng,Bokui Xiao,Guirong Wang,Zezhang Tao-2013-04-01-Annals of Otology Rhinology & Laryngology
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TL;DRAbstract

Exogenous SP-A had a significant therapeutic effect in mice with AR, and its mechanisms of action included inhibition of the differentiation of Th2 cells in the nasal mucosa, reduced levels of Th2 cytokines, and increased levels of Th1 cytokines. Together, these effects corrected the Th1/Th2 imbalance, inhibited the increase of specific immunoglobulin E production, effectively reduced the symptoms of AR, and inhibited the development of AR.

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Exogenous SP-A had a significant therapeutic effect in mice with AR, and its mechanisms of action included inhibition of the differentiation of Th2 cells in the nasal mucosa, reduced levels of Th2 cytokines, and increased levels of Th1 cytokines. Together, these effects corrected the Th1/Th2 imbalance, inhibited the increase of specific immunoglobulin E production, effectively reduced the symptoms of AR, and inhibited the development of AR.

Keywords

OvalbuminNasal administrationH&E stainInterleukinInterleukin 4ImmunologyCytokineImmunoglobulin E

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