The Influence of HPV16, Smoking and Coitarche in the Development of Cervical Dysplasia in the Stage where Conization is the Treatment of Choice

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<p style="text-align: justify;">The high incidence of premalignant lesions of the cervix in our country and worldwide was the primary aim for conducting this study so as to establish whether HPV16, smoking and coitarche (first intercourse) are significant factors in the developmental stages of cervical dysplasia in the case of which the conization is a surgical treatment of choice. In the period of three years, one hundred and thirty-six women from the Republic of Macedonia with histologically confirmed CIN were examined as well as 50 control cases with normal cytology and colposcopic findings. The aforesaid epidemiologic factors examined in this study were obtained through special questionnaires. The resulting material was statistically processed to determine whether these factors are risk factors for development of higher stages of cervical dysplasia. The obtained statistical analysis showed that HPV16, smoking and coitarche under the age of 18 are ver

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