Abstract 8922: Association between Metabolic Syndrome and Concentric Left Ventricular Hypertrophy in Patients with Severe Calcific Aortic Stenosis Undergoing Aortic Valve Replacement

TL;DRAbstract

Background: We reported that in patients with mild to moderate aortic stenosis (AS), metabolic syndrome (MetS) is associated with more pronounced concentric LV hypertrophy. Severe LV concentric hypertrophy has been linked to reduced survival following aortic valve replacement (AVR). The aim of this study was to examine the relationship between MetS and prevalence of LV concentric hypertrophy in patients with severe AS referred to AVR. Method and Results: 510 patients with severe AS underwent isolated AVR. Among 510 patients undergoing isolated AVR, 131 (26%) had the MetS and 109 (21%) had type 2 diabetes (T2D). Patients with T2D or MetS had larger waist circumference (T2D: 106±16; MetS: 104 ±12 vs.noMetS-noT2D: 96±13cm; p<0.0001), higher incidence of hypertension (86; 85 vs. 50%) and coronary artery disease (CAD: 22; 18 vs. 10%) compared to those with noMetS-no T2D. The severity of AS was similar in the 3 groups (Peak aortic jet velocity [Vmax]:417±81; 416 ±81 vs. 424±84mmHg; p=0.13

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