Chemotherapy-induced small bowel perforation in a patient with extrapulmonary small-cell carcinoma of the small bowel.

TL;DRAbstract

Extrapulmonary small cell carcinoma (epsmcc) is rare and represents a clinicopathologic entity distinct from pulmonary small-cell carcinoma. It has been described in all anatomic sites outside the central nervous system1, but most commonly involves the gastrointestinal tract (git), the genitourinary and reproductive systems, the salivary glands and sinuses, and lymph nodes1,2. Overall, epsmcc represents 0.1%–1% of git malignancies3. Within the git, most tumours occur within the large bowel (39%), esophagus (30%), and stomach (8%); only about 3% involve the small bowel4. In a review of epsmcc of the duodenum in 2004, only 9 cases had been reported in the literature5. Clinical presentation often involves weight loss and anorexia, or site-specific symptoms such as abdominal pain, obstruction, bleeding, or mass. Staging workup depends on the site of the primary, but often involves computed tomography (ct) imaging of the chest, abdomen, and pelvis, and git endoscopy. Diagnosis is conf

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