The cuprizone model and multiple sclerosis : disparities and similarities

TL;DRAbstract

Multiple sclerosis (MS) is a chronic, inflammatory and demyelinating disorder of the central nervous system. Although demyelination is still a characteristic entity, it has become increasingly apparent in recent years that substantial axonal destruction and neuronal loss are equally important features. The frequent involvement of grey matter structures has received new impetus. Studies on the pathogenesis of grey matter lesions suggest that its underlying disease mechanisms are unique. Less marked microglia activation in grey compared to white matter lesions is obvious but underlying mechanisms are poorly understood. Adequate animal models are a likewise powerful and irreplaceable tool to study disease pathogenesis. In order to serve as a useful model, it should be similar in its aetiology or phenotype. The recognition of the importance of grey matter pathology in MS did lead to the desire for animal models that display grey matter damage. Within the scope of the presented thesis, I ch

Chat with Paper

AI Agents for this Paper