The role of virus neutralization in primate lentivirus pathogenesis

TL;DRAbstract

<p>The antiviral neutralizing activity of sera from primate lentivirus-infected human and monkey hosts was studied. In addition, factors affecting the neutralization reaction were investigated. In simian immunodeficiency virus (SIVsm)-infected macaque monkeys, SIVsm variants able to escape neutralization emerged regularly. Long-term survivor monkeys were able to produce neutralizing antibodies against several escape variants showing a broadly cross-reactive neutralizing activity. In contrast, no neutralization escape mutants could be detected in asymptomatic HIV-2-infected monkeys and all subsequent isolates maintained the same biological phenotype as the virus inoculum. The asymptomatic HIV- 2-infected monkeys were subsequently challenged with pathogenic SIVsm.</p><p>High-titre neutralizing antibodies against SIVsm were detected in all vaccinated monkeys as early as one month after challenge but were not present in all unvaccinated control monkeys. All four control m

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