Abstract 5: Indirect Brain Injury Resulting from Severe Burns Results in Estrogen-Reversible Elevations of Markers of Alzheimer's Disease

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Background: Prior studies have found that patients with severe burns may suffer neurocognitive changes. While frequently attributed to psycho-social issues, recent data from our lab revealed a substantial, rapid and sustained (30 min - 7 day) increase in rat brain inflammation following burns that is blunted by a single post-burn dose of estrogen. Other brain injury processes, such as TBI and stroke have shown an accelerated accumulation of Aβ40, Aβ42, and pTau, leading to a clinical picture of early Alzheimer's disease (AD). We hypothesized that similar AD processes may be triggered in severe burn injury, and altered by post-burn estrogen. Methods: 149 male rats were given a 3° 40% TBSA scald burn. Rats were randomized into 3 groups: Group 1 (0.5mg/kg of 17β estradiol (E2) 15 min after injury); Group 2 (placebo); and Group 3 (sham-burn control). These rats were sequentially sacrificed at 0.5, 1, 2, 4, 6, 8, 12, 18, 24 hours post-burn. An additional 24 rats were sacrificed 7 days post-

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