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Open AccessArticle10.1016/s0021-9258(18)77024-5

THE MECHANISM OF EPINEPHRINE ACTION

Carl F. Cori,Gerty T. Cori-1929-11-01-Journal of Biological Chemistry
46

TL;DRAbstract

It has been shown in a previous paper that subcutaneous injections of epinephrine lead to an increase in blood lactic acid of rabbits and cats (1).The effect was more pronounced in the former species than in the latter.This increase in blood lactic acid after epinephrine injection was also observed in men (2) and rats (3) and it seems likely therefore that it occurs in all mammals.Other experiments made it seem probable that the lactic acid which was found in increased amounts in the blood had its source in muscle glycogen, since the latter was found to diminish after epinephrine injections (4, 5).In the rat it is possible to analyze the body in toto for glycogen and not merely corresponding muscles before and after injection.Non-glycosuric doses of epinephrine caused a disappearance of muscle glycogen in fasting rats in which the glycogen remained practically constant when no injection was given (5).The animals were killed 3 hours after the injection while active absorption of epineph

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It has been shown in a previous paper that subcutaneous injections of epinephrine lead to an increase in blood lactic acid of rabbits and cats (1).The effect was more pronounced in the former species than in the latter.This increase in blood lactic acid after epinephrine injection was also observed in men (2) and rats (3) and it seems likely therefore that it occurs in all mammals.Other experiments made it seem probable that the lactic acid which was found in increased amounts in the blood had its source in muscle glycogen, since the latter was found to diminish after epinephrine injections (4, 5).In the rat it is possible to analyze the body in toto for glycogen and not merely corresponding muscles before and after injection.Non-glycosuric doses of epinephrine caused a disappearance of muscle glycogen in fasting rats in which the glycogen remained practically constant when no injection was given (5).The animals were killed 3 hours after the injection while active absorption of epineph

Keywords

EpinephrineAction (physics)Mechanism (biology)ChemistryMechanism of actionInternal medicineBiochemistryMedicine

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