TL;DRAbstract
Objective To evaluate the practicability of 99Tc(superscript m)-octreotide as an imaging agent of somatostatin receptor-positive tumors. Methods Preparation of 99Tc(superscript m)-octreotide was that technetium-99m was labeled directly with cold kit of octreotide. ①Animal biodistribution experiment: Twenty-five normal and fifteen tumor-bearing mice were injected with 99Tc(superscript m)-octreotide in 0.1 ml containing 3.7 MBq. The biodistribution was performed in routine methods and the percentage of radioactivity administered dose per gram of tissue (%ID/g) and target to non-target ratios (T/NT) at different interval were calculated. ②Imaging of rumor-bearing mice: Five tumor-bearing mice were imaged respectively at 1.2, 3, 4.6, 24 h pi and calculated target to background ratios (T/B). Results ①The normal mice biodistribution indicated that the blood radioactivity presented peak [(3.20±0.54)% TD/g] at 30 mm pi and 99Tc(superscript m)-octreotide were cleared rapidly thereafter. Physiol
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Objective To evaluate the practicability of 99Tc(superscript m)-octreotide as an imaging agent of somatostatin receptor-positive tumors. Methods Preparation of 99Tc(superscript m)-octreotide was that technetium-99m was labeled directly with cold kit of octreotide. ①Animal biodistribution experiment: Twenty-five normal and fifteen tumor-bearing mice were injected with 99Tc(superscript m)-octreotide in 0.1 ml containing 3.7 MBq. The biodistribution was performed in routine methods and the percentage of radioactivity administered dose per gram of tissue (%ID/g) and target to non-target ratios (T/NT) at different interval were calculated. ②Imaging of rumor-bearing mice: Five tumor-bearing mice were imaged respectively at 1.2, 3, 4.6, 24 h pi and calculated target to background ratios (T/B). Results ①The normal mice biodistribution indicated that the blood radioactivity presented peak [(3.20±0.54)% TD/g] at 30 mm pi and 99Tc(superscript m)-octreotide were cleared rapidly thereafter. Physiol
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