Влияние изменения тиреоидного статуса на микроскопические изменения структуры печени крыс при стрессе

TL;DRAbstract

In the experiments on 130 mongrel white male rats weighing 220-250 g it has been established that «free swimming in a cage» (FSC) stress (5 animals were placed in standard plastic cages filled with water up to the level of 15 cm and closed with a net) for an hour influences the histological structure of the liver: at the alarm stage of stress reaction (an hour after FSC) it causes dystrophic changes of hepatocytes and increased blood flow in the liver lobules, which continue at the resistance stage as well (48 hours after FSC); at the exhaustion stage (FSC within 10 days) it causes greater dystrophy of hepatocytes, the occurrence of necrosis in them and microcirculatory disturbances in the lobules. The introduction of mercazolil (intragastrically in the doses 25 mg/kg during 20 days) per se alters the histostructure of the liver tissue, at the alarmand resistance stages of stress reaction it determines more pronounced dystrophy of hepatocytes and microcirculatory disturbances in the lo

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