Prevention of cerebral ischaemic reperfusion injury by intra-arterial administration of superoxide dismutase in the rat

TL;DRAbstract

An experimental test was performed to determine whether superoxide dismutase, an oxygen-free radical scavenger, reduces neurological dysfunction after transient global cerebral ischaemia. Three groups of 13 rats each were used. Group 1 served as normal controls. Groups 2 and 3 were subjected to transient global cerebral ischaemia. Before ischaemia, the right carotid bifurcation was isolated and the right external carotid artery was retrogradely cannulated, with the catheter tip positioned near the origin of the internal carotid artery. Once global cerebral ischaemia was complete, either isotonic saline (group 2) or superoxide dismutase solution (group 3) was injected through the above-mentioned catheter, before, during and after reperfusion. Consequently, the injected solutions were distributed through the circle of Willis to all of the ischaemic brain tissue. Somatosensory evoked potentials were registered in the three groups of animals and were used as a measure of neuronal function.

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