The renin-angiotensin system in obesity : metabolic and hemodynamic effects

TL;DRAbstract

Abdominal obesity plays a central role in the metabolic syndrome and is a major risk factor for type 2 diabetes mellitus and cardiovascular disease. Unravelling the underlying mechanisms of obesity and obesity-related metabolic and hemodynamic disorders, such as insulin resistance and hypertension, may increase the rationale for dietary and/or pharmacological strategies to prevent or treat type 2 diabetes and cardiovascular disease. There is substantial evidence for the involvement of the renin-angiotensin system (RAS) in obesity-related disorders, as extensively reviewed in chapters 1 and 2. Both animal and human studies support the idea that increased RAS activity may lead to insulin resistance and hypertension. With respect to increased RAS activity in obesity, it is tempting to postulate that the RAS in adipose tissue may exert autocrine, paracrine and/or endocrine effects that may contribute to obesity-related disorders. This thesis describes a variety of studies that investigated

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