Radiation-induced abnormality and growth disturbance in the mouse fetus

TL;DRAbstract

Six hundred and forty pregnant mice of ddY strain with the mean frequency distribution of 9.41 plus or minus 2.30 litter size and 6.020 of their fetuses were examined in the experiment. Pregnant mice with fetuses at the gestation age between 7 to 13 days old were irradiated with 200 R (3.3 R/min) of gamma radiation at 2 pm, 7 pm, and 12 am respectively except those with 11-day- old fetuses who received 200 R of irradiation at 4 am, 9 am, 2 pm, and 12 am. In order to obtain correlation between the rate of abnormality in the limbs and radiation dose, 11-day-old fetuses were irradiated with 75, 100, 150, 200, 250, and 300 R for 1 hr. respectively. All of these irradiated groups of fetuses were taken from the maternal body and observed by microscopy. Abnormality appeared first in the forelimbs of the 11-day-old fetuses followed by abnormality found in the hindlimbs. Bradyphalangia was observed in 50% of the 11-day-old fetuses, while congenital anomalies of the hand and fingers were observe

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