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Open AccessArticle10.17116/jnevro20151154273-79

Morphine-induced Straub tail reaction as a model of spasticity in mice: effects of serotonergic compounds

Irina Belozertseva,О. А. Драволина,M. А. Tur,Savelii R. Kuvarzin,Edwin Zvartau-2015-01-01-S S Korsakov Journal of Neurology and Psychiatry
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TL;DRAbstract

The centrally acting muscle relaxant baclofen (3-10 mg/kg) reduced SR induced by morphine (40 mg/kg) at all used doses; tizanidine decreased the intensity of SR at highest doses tested (0.6 and 1 mg/kg). Dantrolene (20-100 mg/kg), a peripherally acting muscle relaxant, did not affect SR. Effects of serotonergic agents depended on the specific mechanism of action. SR appears to be available for rapid evaluation of the effect of antispasticity drugs.

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The centrally acting muscle relaxant baclofen (3-10 mg/kg) reduced SR induced by morphine (40 mg/kg) at all used doses; tizanidine decreased the intensity of SR at highest doses tested (0.6 and 1 mg/kg). Dantrolene (20-100 mg/kg), a peripherally acting muscle relaxant, did not affect SR. Effects of serotonergic agents depended on the specific mechanism of action. SR appears to be available for rapid evaluation of the effect of antispasticity drugs.

Keywords

SerotonergicMorphineMedicineMuscle relaxantBaclofenSpasticPharmacologySpasticity

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