TH-CD-207-01: BEST IN PHYSICS (IMAGING): Correction of the First-Pass Distortion in Arterial Input Function of DCE MRI for Perfusion Quantification

TL;DRAbstract

Purpose: To quantify perfusion in an abdominal organ (liver, spleen or kidney) from dynamic contrast-enhanced (DCE) MRI, an arterial input function(AIF) is commonly sampled in a volume of interest (VOI) on the descending aorta. However, the peak of the first pass of the AIF could be corrupted, due to the T2* effect of high contrast-concentration, particularly at 3T MR, and other factors. This study aimed to correct this distortion in the AIF for DCE MRI perfusion quantification of an abdominal organ. Methods: A post-processing correction method was developed to automatically recognize the distortion portion in the first pass of an AIF and fit it with a gamma-variate function. The fitting of the first pass was incorporated in pharmacokinetic(PK) modeling of the DCE curves from VOIs in both spleen and kidney. The optimal solution was determined by balancing between best fitting the PK model and matching the fitted first pass with the measured one. The corrected AIFs were applied to quant

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