Direct current insulator based dielectrophoresis (DC-iDEP) microfluidic chip for blood plasma separation

TL;DRAbstract

Lab-on-a-Chip (LOC) integrated microfluidics has been a powerful tool for new developments in analytical chemistry. These microfluidic systems enable the miniaturization, integration and automation of complex biochemical assays through the reduction of reagent use and enabling portability.Cell and particle separation in microfluidic systems has recently gained significant attention in many sample preparations for clinical procedures. Direct-current insulator-based dielectrophoresis (DC-iDEP) is a well-known technique that benefits from the electric field gradients generated by an array of posts for separating, moving and trapping biological particle samples. In this thesis a parametric optimization is used to determine the optimum radius of the post for particle separation. Results that are used to design a microfluidic device that with a novel combination of hydrodynamic and di-electrophoretic techniques can achieve plasma separation in a microfluidic channel from fresh blood and for

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