Evaluation of anti-inflammatory activity of selected medicinal plants used in Indian traditional medication system in vitro as well as in vivo
TL;DRAbstract
The present study was carried out to evaluate <i>in vivo</i> and <i>in vitro</i> anti-inflammatory potential of selected medicinal plants used in Indian traditional medication. The sequentially extracted plant samples as, <i>Cissus quadrangularis</i>, <i>Plumbago zeylanica</i>, <i>Terminalia bellarica</i> and <i>Terminalia chebula</i> in water, ethanol and hexane were evaluated <i>in-vitro</i> for COX-1 and 2 inhibitory and antioxidant activities. The <i>in vivo</i> anti-inflammatory activity of selected samples showing promising COX-2 inhibition was assessed using carrageenan and Phorbol Myristate Acetate (PMA) induced mice edema animal model. The results obtained reveals that most of the plants were found to inhibit COX-2 activity as compared to COX-1. It was observed that the extracts of <i>T. bellarica</i> (73.34 %) and <i>T. chebula</i> (74.81 %) showed significant COX-2 selective inhibition as compared to other samples. The ethanol extract of the selected plants demonstrated effe
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The present study was carried out to evaluate <i>in vivo</i> and <i>in vitro</i> anti-inflammatory potential of selected medicinal plants used in Indian traditional medication. The sequentially extracted plant samples as, <i>Cissus quadrangularis</i>, <i>Plumbago zeylanica</i>, <i>Terminalia bellarica</i> and <i>Terminalia chebula</i> in water, ethanol and hexane were evaluated <i>in-vitro</i> for COX-1 and 2 inhibitory and antioxidant activities. The <i>in vivo</i> anti-inflammatory activity of selected samples showing promising COX-2 inhibition was assessed using carrageenan and Phorbol Myristate Acetate (PMA) induced mice edema animal model. The results obtained reveals that most of the plants were found to inhibit COX-2 activity as compared to COX-1. It was observed that the extracts of <i>T. bellarica</i> (73.34 %) and <i>T. chebula</i> (74.81 %) showed significant COX-2 selective inhibition as compared to other samples. The ethanol extract of the selected plants demonstrated effe
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