Abstract 601: Haptoglobin Genotype Determines Myocardial Infarct Size in Diabetic Mice

TL;DRAbstract

Objectives. We sought to understand the importance of oxidative stress in explaining why the haptoglobin (Hp) genotype determines myocardial infarction (MI) size in diabetes mellitus (DM). Background. Two common alleles (1 and 2) exist at the Hp locus in man. The haptoglobin (Hp) 2 allele is associated with increased MI size in individuals with DM. Enhanced oxidative stress resulting in increased production of reactive oxygen species has been shown to play a critical role in the generation of myocardial ischemia-reperfusion injury (IR). Redox active labile plasma iron (LPI) and the anti-inflammatory cytokine interleukin-10 (Il-10) are known to play major roles in determining the extent of myocardial injury after myocardial IR. In vitro the Hp 2 protein is associated with increased generation of oxidatively active iron while the Hp 1 protein is associated with increased production of the antioxidant cytokine interleukin-10 (Il-10). Methods. MI was produced by myocardial ischemia-reperfu

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