Treatment of Intermittent Claudication due to Peripheral Arterial Disease

TL;DRAbstract

Peripheral arterial disease may cause intermittent claudication which is pain or weakness with walking that is relieved with rest [1]. Patients with intermittent claudication should be treated with optimal medical therapy to reduce cardiovascular death, nonfatal myocardial infarction, and stroke and also to improve exercise time until intermittent claudication [1]. Optimal medical therapy to reduce cardiovascular events and mortality in patients with peripheral arterial disease include smoking cessation programs [1], treatment of hypertension [1-3], treatment of hypercholesterolemia [1,4], treatment of diabetes mellitus [1,5], antiplatelet drug therapy [1,6-8], treatment with an angiotensin-converting enzyme inhibitor [1,3], treatment with high-dose statins [1,4,9], and treatment with beta blockers if indicated in patients with mild-to moderate peripheral arterial disease [1,10]. Vorapaxar [11] has recently been approved by the United States Food and Drug Administration to treat patien

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