TL;DRAbstract
One of the most important outgrowths of the discovery of proinsulin was the finding that the 31-residue connecting segment, or C-peptide, that joins the insulin chains in the prohormone is excised intact and secreted in equal amounts along with insulin. This finding allowed the development of the human C-peptide radioimmunoassay which has become indispensable as an accurate measure of insulin production in vivo in various forms of diabetes [1].
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One of the most important outgrowths of the discovery of proinsulin was the finding that the 31-residue connecting segment, or C-peptide, that joins the insulin chains in the prohormone is excised intact and secreted in equal amounts along with insulin. This finding allowed the development of the human C-peptide radioimmunoassay which has become indispensable as an accurate measure of insulin production in vivo in various forms of diabetes [1].
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