Influence of <I>Tripterygium wilfordii</I> on the expression of sper-miogenesis related genes <I>Herc4, Ipo11</I> and <I>Mrto4</I> in mice

TL;DRAbstract

The mechanism of Tripterygium wilfordii (GTW) inhibiting productive function was studied in the male mice. The male mice were randomly divided into control group and GTW group. GTW group had been given Tripterygium wilfordii for 8 weeks. The pregnancy rate was investigated after the male mice mated with the normal female mice (1ratio2) in one week. Also the pathological changes of the male mice testis were evaluated by the optical microscope and the expression of genes related to reproduction was investigated by Gene Chip Technology 8 weeks later. The results showed pregnancy rate of GTW group was obviously decreased compared with the control mice, and no pregnancy occurred in GTW group at 8 weeks. In the testis tissues of GTW group, the spermatogenic cells in the convoluted seminiferous tubules were obviously decreased and the lumen was obstructed by large deciduous spermatogenic cells. The number of abnormal expression genes in this group was 1 932. Among them, 354 genes were related

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