The role of cyclic strain on miRNA mediated human aortic smooth muscle cell (HAoSMC) dynamics

TL;DRAbstract

Vascular smooth muscle cells (VSMCs) are major contributors to regulation of vascular tone through their contractile flexibility. Along with other stimulus, they are exposed to mechanical cyclic strain. It is thought such stimulus can be a major regulator of phenotypic modulation in smooth muscle cells. Differentiated SMCs are characteristically quiescent and adapt elongated spindle morphology. In this state the cell expresses an extensive range of contractile proteins such as SM α-actin, Smoothelin and Calponin. SMCs in the synthetic end of the phenotype spectrum adapt a rhomboid morphology and display increased growth rate and higher migratory activity. Expression of the contractile proteins are significantly decreased and replaced with organelles involved in protein synthesis.\nStudies have shown that several non coding micro RNA (miRNA), which negatively regulate gene expression, are differentially expressed in altered SMC phenotypes. However, work into the effect of mechanical sti

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